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Preparation of 3-Bromo-2,4,6-Trimethyl Hida and Its 99MTc-Complex for Hepatobiliary Imaging
Correspondence to: Kh. Nurmatov Institute of Nuclear Physics, Academy of Sciences, 100214, pos. Ulugbek, Tashkent, Republic of Uzbekistan Ph. 998713692278, Fax: 998713693560 Email: sherzodn@yandex.ru
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This article was originally published by Wolters Kluwer - Medknow and was migrated to Scientific Scholar after the change of Publisher.
Abstract
3-bromo-(2,4,6-trimethylphenylcarbamoylmethyl) iminodiacetic acid (3-bromo-2,4,6-trimethyl HIDA) was synthesized, and lyophilized vials were prepared which contained 20 mg of 3-bromo-2,4,6-trimethyl HIDA and 0.4 mg of SnCl2. Radiochemical and biologic studies showed that this agent was obtained in high radiochemical purity, were stable in vitro and in vivo conditions. The compound, 99mTc-3-bromo-2,4,6-trimethyl HIDA, possessed high hepatic specificity meaning that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and rapid hepatocellular transit and a rapid clearance from the blood circulation was observed. In conclusion, a lyophilized kit of HIDA and its labeling with 99mTc can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.