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Comparison of Gallium-67 and Tc-99m Tetrofosmin Uptake in Lymphoma
Correspondence to: Dr. R. KrishnaKumar, M.D., DRM Professor & Head Department of Nuclear Medicine Cancer Institute (WIA) Adyar, Chennai-600 020, INDIA Phone: 091-044-22350131, 22350241 Fax: 091-044-24912085 E-mail: krishmanju12@yahoo.com
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This article was originally published by Wolters Kluwer - Medknow and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Scintigraphic evaluation of lymphomas with Gallium67 (Ga-67) pre & post—therapy is well-established procedure. Other agents employed include 18Fluoro Deoxy Glucose (FDG) and Thallium chloride (Tl- 201). However Ga-67, 18FDG and Tl-201 are all cyclotron produced and are not readily available in developing countries like India. In this context assuming similarity of behavior with the myocardial perfusion scanning agent Tl- 201, the newer Technetium-99m (Tc-99m) labeled myocardial perfusion scanning agents have been studied in imaging of various tumors.
Methods:
13 patients of lymphoma —Hodgkin's disease (HD) and Non Hodgkin's Lymphoma (NHL) in various stages were studied. Tc-99m Tetrofosmin (Tf) (Myoview-source Nycomed Amersham Pic, England was injected intravenously and static images of the involved site were taken at 5 minutes, one hour and again at 24 hours. Static images of the skull, chest, axillae, abdomen and pelvis were acquired at 30 minutes. Subsequently 5 patients were studied with Ga-67. The images were compared.
Results:
The total number of clinically involved sites in 13 patients were 75 and 99mTc-Tf uptake was seen in 16 sites only (20%). Of the 5 patients who had both the studies the total number of clinically involved sites were 25. 99mTc-Tf uptake was seen in 8 sites whereas Ga-67 uptake was seen in 11 sites (44%). 99mTc-Tf uptake in abdominal sites was masked by hepatobiliary excretion
Conclusion:
Ga-67 is superior to 99mTc-Tf in imaging lymphoma.
