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Code Blue Response in Radionuclide Therapy Wards: A Standard Operating Procedure for Emergency Care and Radiation Safety
*Corresponding author: Dr. Dibya Prakash, Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Utsav Chowk - CISF Rd, Owe Camp, Kharghar, Navi Mumbai, Maharashtra 410210, India. dibyaprakash11@gmail.com
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Received: ,
Accepted: ,
How to cite this article: Prakash D, Agrawal A, Trivedi BD, M. Venkatachalam M, Paunikar S, Chauhan MH, et al. Code Blue Response in Radionuclide Therapy Wards: A Standard Operating Procedure for Emergency Care and Radiation Safety. Indian J Nucl Med. 2026;41:61-77. doi: 10.25259/IJNM_18_2026
Abstract
High-dose radionuclide therapy wards present unique challenges during medical emergencies because patients receiving therapeutic radiopharmaceuticals continue to emit ionising radiation while being managed in isolation. Standard hospital Code Blue protocols are designed for conventional clinical environments and do not address radiation exposure, radioactive contamination risks, responder protection, or coordination with radiation safety services. Conversely, existing radiation protection guidelines focus primarily on routine clinical practice and contamination control, and provide limited operational guidance for managing acute medical emergencies such as cardiac arrest. In real-world settings, healthcare providers responding to Code Blue events in radionuclide therapy wards must therefore balance the urgency of life-saving interventions with radiation safety considerations, underscoring the need for a clear, integrated, and practical standard operating procedure to guide effective and safe emergency response.
This continuing medical education (CME) article provides a structured, practical Standard Operating Procedure (SOP) for managing Code Blue emergencies in high-dose radionuclide therapy wards. The SOP integrates American Heart Association life-support principles with internationally accepted radiation safety guidance from the International Atomic Energy Agency, International Commission on Radiological Protection, World Health Organisation, and national regulatory authorities. Key components include early recognition and activation of Code Blue, clearly defined multidisciplinary roles, exposure control strategies based on time, distance, and shielding, contamination prevention measures, thyroid blockade protocols for radioiodine exposure, and safe post-event decontamination practices.
Special emphasis is placed on the role of the Radiological Safety Officer in real-time supervision, dose monitoring, contamination control, and documentation during emergency response. The article also outlines recommended dose constraints for responders, ethical considerations during life-saving interventions, and the importance of regular training and simulation drills.
This SOP is intended as an educational framework to support preparedness, improve responder confidence, and enhance safety during emergencies in radionuclide therapy settings. The principles described are adaptable to a wide range of nuclear medicine facilities and are designed to complement existing institutional Code Blue policies while maintaining compliance with radiation protection standards.
Keywords
Code blue preparedness
radiation safety
Continuing medical education
Emergency response protocol
Health services organisation
Radiation emergency preparedness
Radionuclide therapy
INTRODUCTION
High-dose radionuclide therapy is an important modality within nuclear medicine, particularly for the treatment of malignancies such as thyroid cancer, neuroendocrine tumours, neuroblastoma, and prostate cancer. Large quantities of radiopharmaceuticals, including Iodine-131 (I-131) (3.7-9.25 GBq) for thyroid cancer, Lutetium-177 (Lu-177)-labelled radiopharmaceuticals (7.4 GBq), meta-Iodobenzylguanidine (131I-mIBG) (3.7-29.6 GBq) for neuroblastoma, alpha therapies such as Actinium-225 (50-200 kBq/kg), and Terbium-161-labelled radiopharmaceuticals (4.81-5.18 GBq), are administered in specialised therapy wards. Patients undergoing these treatments emit significant radiation, which poses unique challenges during emergency situations. For example, a patient administered 7.4 GBq of I-131 may emit approximately 10 mSv/hour (~1 R/hour) at the abdominal region and about 0.5 mSv/hour (~50 mR/hour) at a distance of 1 meter, necessitating strict radiation safety precautions.
The American Heart Association (AHA), in its guidelines, defines a "Code Blue" situation.[1] This condition necessitates immediate activation of the resuscitation team and initiation of cardiopulmonary resuscitation (CPR) in accordance with established AHA cardiac arrest management protocols. While the AHA does not mandate a specific response time, best practices and institutional benchmarks suggest team arrival within 2-3 minutes, as supported by observational and quality improvement studies.[2-5]
These considerations highlight the need for an integrated, practice-oriented framework that aligns emergency resuscitation protocols with radiation safety requirements in high-dose radionuclide therapy wards.
Clinical rationale
International studies indicate that in-hospital cardiac arrest (IHCA) incidence ranges from approximately 1.5 to 5 per 1,000 hospital admissions in countries such as the UK, Italy, Japan, and Australia/New Zealand, while isolated reports (e.g., Abu Dhabi) describe higher rates.[1,6–8] In-hospital cardiac arrest is most commonly caused by hypoxia (21%), followed by acute coronary syndrome (14%), arrhythmias (12%), hypovolaemia (12%), infection (11%), unknown causes (11%), and heart failure (10%). Less frequent causes include neurological events (2%), pulmonary embolism (2%), cardiac tamponade (2%), electrolyte disturbances (2%), toxins (1%), and pneumothorax (0.1%), as reported in a large systematic review and meta-analysis with associated 95% confidence intervals ranging from hypoxia (14.2%-38.7%) to pneumothorax (0.06%-0.14%).[9,10]
No specific data exist characterising Code Blue activation rates in nuclear medicine or high-dose therapy wards. In nuclear medicine therapy wards, the absence of radiation-integrated emergency response protocols represents a critical gap in preparedness. Healthcare providers responding to a Code Blue situation in a nuclear medicine therapy ward must therefore balance rapid resuscitation efforts with radiation protection measures to prevent external exposure and internal contamination.
This Standard Operating Procedure (SOP) has been developed to address these challenges by ensuring:
Prompt and effective resuscitation in alignment with AHA-recommended life-support guidelines.
Minimisation of radiation exposure to healthcare providers, with protocols to prevent external irradiation and internal contamination (e.g., I-131 uptake through inhalation or ingestion).
Safe post-mortem handling of radioactive patients, ensuring compliance with radiation safety standards when managing deceased individuals with residual radioactivity.
This SOP is based on internationally recognised guidelines from the International Atomic Energy Agency (IAEA), the International Commission on Radiological Protection (ICRP), the AHA, and the World Health Organisation (WHO). By integrating radiation safety protocols with established resuscitation procedures, this document provides a comprehensive, evidence-based framework to enhance emergency response preparedness, healthcare worker safety, and patient care in high-dose radionuclide therapy facilities worldwide.
Standard operating procedure (educational framework) for code blue in radionuclide therapy wards
This Standard Operating Procedure (SOP) provides a structured, step-by-step framework for managing Code Blue emergencies in nuclear medicine therapy wards. It defines role-specific responsibilities, emergency response sequences, and essential radiation safety measures, ensuring seamless integration of life-saving interventions with contamination control and exposure minimisation strategies. Emphasis is placed on shielding techniques, contamination containment, and real-time dosimetry monitoring to protect healthcare providers while delivering timely resuscitation. The framework adheres to internationally recognised radiation safety and resuscitation standards, offering a practical and replicable model for emergency response in high-dose radionuclide therapy settings.
This SOP was developed through a multidisciplinary collaborative process involving Nuclear Medicine physicians, Radiological Safety Officers, anaesthetists, nursing staff, and hospital emergency response personnel. The SOP was reviewed and approved by relevant institutional bodies prior to implementation.
To ensure clarity and ease of implementation, this SOP comprises 11 sections, each detailing procedural steps, equipment specifications, and safety protocols necessary for effective execution. These sections are designed to facilitate adoption by nuclear medicine facilities worldwide and to support integration into institutional emergency preparedness programs.
Objective
This SOP is designed to ensure a safe and effective response to Code Blue emergencies in high-dose radionuclide therapy wards. It establishes protocols that balance rapid medical intervention with radiation safety, protecting both patients and healthcare providers. The key objectives include:
Ensuring medical efficacy through immediate CPR and advanced life support (ALS) to restore circulation and oxygenation.
Minimising radiation exposure to responding personnel (target: <5 mSv per incident) while preventing contamination.
Safeguarding the environment by containing radioactive waste and reducing secondary exposure risks.
Managing post-mortem procedures safely when dealing with deceased patients who may still have residual radioactivity (e.g., I-131 half-life: 8.02 days).
Scope
This SOP applies to all personnel responding to Code Blue emergencies in high-dose radionuclide therapy wards, where both life-saving interventions and radiation protection must be carefully managed. It covers:
Personnel involved: Physicians, Radiological Safety Officer (RSO), nurses, emergency response teams, and support staff such as porters, cleaners and security staff.
Radiopharmaceuticals administered: Iodine-131 (volatile, thyroid uptake risk), Lutetium-177 (beta-gamma emitter) labelled radiopharmaceuticals, 131I-mIBG (beta-gamma emitter), Terbium-161 labelled radiopharmaceuticals (beta-gamma emitter), and Actinium-225 labelled radiopharmaceuticals or alpha therapies (high LET, short-range).
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Radiation risks addressed:
External exposure from high-dose patients.
Internal contamination via inhalation, as iodine-131 can become airborne, being volatile in nature, and absorbed by the thyroid.
Body fluid contamination, as certain radiopharmaceuticals, such as iodine-131, are excreted significantly, with up to 50-60 % in urine within 24 hours and around 85% during a stay of 3-5 days.[11]
To ensure safe and effective emergency response, institutions should provide specialised training on isotope-specific hazards, such as thyroid protection protocols for iodine-131 exposure.
Definition of a code blue situation and the need for special radiation safety precautions
The American Heart Association, in its guidelines, suggests "Code Blue is a situation where a patient is unresponsive, shows no normal breathing (only gasping or apnea), and no pulse is detected within 10 seconds". This condition necessitates immediate activation of the resuscitation team and initiation of cardiopulmonary resuscitation (CPR) as per the established AHA Cardiac Arrest Management protocols. In high-dose radionuclide therapy wards, these emergencies present additional challenges due to:
Elevated radiation levels from the patient can reach 1.5 to 10 mSv per hour at the abdomen, depending on the patient's habitus and administered activity (ranging from 50 to 250 mCi if I-131; Institutional experience). These dose rates significantly exceed background levels and pose exposure risks to healthcare providers during resuscitation.
Potential contamination risks, such as radioactive body fluids, with concentrations reaching 1 to 10 MBq per millilitre in urine.[11,12]
Institutions should establish specific criteria for triggering a Code Blue, such as an absence of pulse for more than 10 seconds and conduct regular training exercises to ensure staff are familiar with both medical and radiation safety protocols in emergency scenarios.
Personnel involved in code blue response
Managing a Code Blue in high-dose radionuclide therapy wards requires a coordinated effort among multiple personnel, each with defined roles to ensure both medical efficacy and radiation safety. The personnel can be divided into first responders, primary responders, and the Hospital Code Blue Team, which is specialised to provide Advanced Life Support (ALS).
First responder (ward staff, e.g., nurse)
First responder can be anyone who sees the emergency, examines the condition, and activates the Code Blue. If the responder is alone, activate the code blue by dialling the emergency number (e.g., 2222) and/or announce on the hospital public address (PA) system as the situation permits.
Initiates cardiopulmonary resuscitation (CPR) at 100-120 compressions per minute.
If two people are present, one person can activate the Code Blue, and the other can initiate CPR.
Primary responders
Once the code blue is announced, the Primary responders, i.e., ward nurses, RSOs, and Nuclear Medicine Physicians, are to rush to the site as announced and perform the following:
Ward nurses
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Wear appropriate personal protective equipment (PPE):
Double nitrile gloves (0.1 mm thick), Tyvek gown, shoe covers, and a thermo-luminescent dosimeter (TLD) badge clipped to the chest for radiation monitoring, and if available, wear a digital pocket dosimeter.
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Assess the patient's condition:
Check pulse (carotid for adults/children, brachial for infants, ≤10 seconds), breathing status, and level of consciousness using the AVPU scale (Alert, Verbal, Pain, Unresponsive).
Rapidly deploy the crash cart with requisite life-saving drugs to the code blue site, ensuring immediate availability of critical equipment, including:
Defibrillator: Biphasic, pre-charged to 120-200 J, with disposable pads covered in 0.1 mm plastic sheets to prevent radioactive contamination.
Oxygen cylinder: Portable, 10 L capacity, with a flow rate of 10-15 L/min, fitted with a disposable regulator.
Ambu bag: Adult and paediatric sizes, with disposable airways to minimise contamination risks.
Radiological safety officer (RSO)
Oversees radiation protection: Ensure radiation safety protocols are adhered to and ensure that everyone involved wears all protective gear and radiation monitors. Ensures responders' exposure remains below safety limits (e.g., 5 mSv per episode for non-radiation workers, 20 mSv/year for radiation workers.[13,14]
Ensure intake of thyroid blockade: Coordinate with the Nuclear Medicine Physician to administer stable Potassium Iodide (KI, 130 mg tablets) to personnel handling Code Blue for I-131-treated patients.[15] Also, ensure the availability of the thyroid blocking agent.
Assess radiation level & radiopharmaceutical administration history: Assess the patient's administered activity (e.g., Iodine-131 [I-131], 7.4 GBq [200 mCi], 48 hours post-administration, ~2.5 mSv/hour at 1 m) to estimate radiation exposure and contamination risks.
Monitor contamination: Use a calibrated radiation survey meter to assess ward and environmental contamination levels. The Surface Contamination Levels in Restricted Areas is to be below 33 Bq (2,000 dpm) per 100 cm2 for I-131 and Lu-177 isotopes as per The United States Nuclear Regulatory Commission (USNRC) Nuclear Regulatory Commission (NUREG) technical report series - 1556(Consolidated Guidance About Materials Licenses).[16]
Ensures availability of radiation safety supplies: Maintain stock of absorbent sheets, radioactive waste bins, plastic sheets to cover instruments, disposal gloves, gown, shoe cover, caps, etc.
Minimises contamination risks: Use of plastic sheets (0.1 mm thick) to cover equipment and surfaces, and places absorbent sheets under patients to contain body fluids (e.g., urine, saliva, stool).
Supervises radioactive waste disposal, including linen: Ensure all contaminated materials (e.g., gloves, absorbent sheets, linen) are sealed in labelled waste bags ("Radioactive, I-131, [Date]") and stored in lead-lined bins until activity decays to background level. Linen is to be stored in separate bags with labels as described. Other waste is to be disposed of as per the hospital bio-medical waste management policy.
Nuclear medicine physicians
Supervise medical interventions: Arrive within five minutes to lead and oversee all life support procedures, including defibrillation (120-200 J biphasic for adults, 2-4 J/kg for paediatrics), airway management (10-12 breaths/min), and intubation (endotracheal tube, 7.5-8.0 mm for adults), ensuring compliance with AHA 2020 guidelines until the Hospital Code Blue Team assumes control.
Prescribe thyroid blockade: Prescribe Super Saturated Potassium Iodide (SSKI) to responders as soon as possible and within 24 hours pre-exposure or ≤2 hours post-exposure for I-131 patients to reduce thyroid uptake by ~80% (WHO, 2018[15]). Details are mentioned in section 3.5.3.
Review radiopharmaceutical history: Coordinate with the RSO to review the patient's radiopharmaceutical administration records. Estimate the residual activity and potential external and internal exposure risks to caregivers and staff, facilitating appropriate radiation protection measures.
Assist Hospital Code Blue: Upon arrival of the Code Blue team, provide a clear and structured handover summarising all interventions performed and the patient's radioactive status. Ensure seamless transition of care while continuing to adhere to radiation safety aspects as needed.
Hospital code blue team (secondary responders)
For effective in-hospital resuscitation (Code Blue events), a team comprising at least four trained personnel is essential, with optimal performance achieved with five to six members, with each assigned clearly defined roles.[17] The resuscitation team is typically interdisciplinary, including one to two attending physicians, resident doctors, two nurses, and one to two paramedics, depending on patient volume.[18] All team members must be certified in Advanced Cardiac Life Support (ACLS). This team structure ensures a high chest compression fraction, efficient administration of advanced life support (ALS), and coordinated response during critical events. A designated team leader may be a senior physician, intensivist, or anaesthesiologist; however, other specialists, including emergency medicine physicians or cardiologists, may also serve effectively in this capacity, depending on institutional protocols and clinical context. Additionally, the Radiological Safety Officer (RSO) should remain an integral part of the team in the high-dose therapy ward to supervise and ensure adherence to radiation safety measures.
Exclusion criteria
As far as possible, pregnant staff are not to be part of the Code Blue Team unless the situation necessitates them to be an integral part of the team and no other option is available. In this situation, the Time, Distance, and Shielding principles of radiation protection are also to be followed. In case she is part of the code blue team, an additional abdominal pocket dosimeter is to be issued (dose limit: 1 mSv), and abdominal doses are to be recorded.
The roles and responsibilities of each member are as follows:
Team leader (senior physician, intensivist, anaesthesiologist, emergency medicine physicians, or cardiologists):
An effective team leader plays an important role in code blue management. This becomes more critical when the resuscitation team is formed ad hoc, a common scenario during off-hours or in resource-limited settings[5] The responsibilities of a team leader include
Initiates and oversees the Code Blue response immediately upon arrival.
Assigns and clarifies team roles based on members' competencies.
Maintains situational awareness and minimises confusion.
Directs the flow of clinical interventions, ensuring timely defibrillation, airway management, and medication administration.
Supervises resuscitation progress in collaboration with other team members.
Determines the decision to terminate resuscitation, particularly if no Return of Spontaneous Circulation (ROSC) is achieved after a reasonable period (commonly ~20 minutes without reversible causes).
Compressor:
He/she is responsible for delivering high-quality chest compressions at a rate of 100-120 per minute and plays a very important role in resuscitation. The definition of high-quality chest compression is mentioned in the AHA 2020 guidelines, part 3,[1],4[19] and 7[20] and suggest that the majority of resuscitation success is achieved by application of high-quality CPR and defibrillation. High-quality chest compressions consist of delivering compressions at an adequate depth, maintaining an optimal rate, minimising interruptions, allowing full chest recoil, and avoiding excessive ventilation. As per AHA guidelines, the role of the compressor is as follows:
Deliver chest compressions at a rate of 100-120 per minute, with a depth of at least one-third the anterior-posterior diameter of the chest i.e. approximately 1.5 inches (4 cm) in infants, 2 inches (5 cm) in children and adults, while avoiding excessive depth greater than 6 cm, as deeper compressions may increase the risk of internal injuries without additional circulatory benefit.
Allow complete chest recoil after each compression to maximise venous return to the heart.
To avoid fatigue and maintain effective compressions, the role should be rotated every 2 minutes.[1] with another trained team member, such as an emergency technician or the monitor/defibrillator operator. Minimise interruptions in compressions to maintain coronary and cerebral perfusion pressure.
Avoid excessive ventilation, as it can increase intrathoracic pressure and compromise venous return.
If an advanced airway is not in place, maintain a compression-to-ventilation ratio of 30:2.
Reassess CPR quality if Partial Pressure of End-Tidal Carbon Dioxide (PETCO2) levels are low or decreasing. The PETCO2 is a measure of CO2 in exhaled air and is a primary indicator of perfusion. It is typically measured in waveform by a capnograph connected to the airway (via mask or endotracheal tube) and depicts low chances of survival or failure to achieve return of spontaneous circulation (ROSC) if its value is <10 mmHg after 20 minutes of CPR.
Airway manager:
He/she is responsible for securing and maintaining a patent airway to ensure effective oxygenation and ventilation during resuscitation. Proper airway management enhances gas exchange and supports perfusion and neurological outcomes.
Airway management during resuscitation involves manual and advanced techniques. The manual technique involves head tilt, chin lift or jaw thrust, and may include suctioning, whereas advanced techniques involve supraglottic airways (e.g., laryngeal mask airway) and endotracheal tubes, with supraglottic devices showing strong safety and efficacy in paediatrics[1,21]
Confirm and monitor airway placement with waveform capnography, the gold standard for verifying endotracheal tube positioning and monitoring CPR effectiveness.[22]
For adults, provide 1 breath every 6 seconds (10 breaths/min) with continuous chest compressions and each breath over 1 second.
In infants and children, ventilate at 20-30 breaths/min (1 breath every 2-3 seconds), adjusted for age and clinical conditions. Avoid hyperventilation to prevent reduced venous return and cardiac output.
For adults receiving bag-valve-mask ventilations during CPR, deliver tidal volumes of approximately 500-600 mL (or just enough to produce a visible chest rise) with each breath given over about 1 second to minimise the risk of gastric insufflation and aspiration.[1, 23]
When administering oxygen via bag-valve-mask (BVM) connected to an oxygen cylinder, set the flow regulator to at least 10-15 L/min to ensure adequate oxygen delivery with a reservoir-equipped BVM.[24]
Coordinate with the team leader and compressor to synchronise ventilation, especially during rhythm checks and team transitions.
Medication nurse:
He/she is responsible for preparing and administering emergency medications during resuscitation, following:
Administer Inj. epinephrine 1 mg intravenous (IV)/Intraosseous (IO) every 3-5 minutes for adults and 0.01 mg/kg with a max dose of 1 mg and repeat with the same every 3-5 minutes.
For non-shockable rhythms (asystole/PEA), give epinephrine as soon as feasible.
For persistent VF/pVT (ventricular fibrillation or pulseless ventricular tachycardia), epinephrine (1 mg IV/IO) may be given every 3-5 minutes starting after the second defibrillation attempt, while continuing CPR and rhythm checks.[25]
IV access is preferred; if unsuccessful or delayed, establish intraosseous (IO) access promptly.
In cases where IV/IO access is not possible, consider endotracheal (ET) drug administration as an alternative route.
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For refractory VF/pVT, consider:
Amiodarone IV/IO: First dose 300 mg bolus; second dose 150 mg for adults and 5 mg/kg for paediatric patients, and repeat up to 3 doses for Refractory VF/pVT.
or Lidocaine IV/IO: First dose 1-1.5 mg/kg; subsequent doses 0.5-0.75 mg/kg for adults and 1 mg/kg for paediatrics.
Coordinate closely with the team leader for drug timing, avoid duplication, and document all doses administered accurately.
Emergency technician:
The emergency technician plays a vital role in supporting the resuscitation team by ensuring the rapid and efficient setup and operation of critical life-saving equipment. Responsibilities include the correct placement and functioning of defibrillator pads, suction apparatus, bag-valve-mask devices, and various oxygen delivery systems. The technician actively assists in maintaining equipment readiness, troubleshooting device malfunctions, and ensuring seamless transitions between interventions. Additionally, the technician facilitates timely patient transport when indicated and may assume alternate roles within the resuscitation team as required, adapting flexibly to the dynamic needs of the clinical scenario.
Recorder: He/she documents all critical details, including:
Time of cardiac arrest (e.g., 16:30).
Initial cardiac rhythm (e.g., ventricular fibrillation).
Interventions performed (e.g., defibrillation at 200 J at 16:33).
RSO during code blue
Supervises the entire procedure with respect to radiation safety protocols and ensures all measures are followed to contain the spillage, overexposure to the staff, while ensuring no compromise on patient care.
Conducts radiation contamination checks to ensure surface readings remain below 50 counts per second (cps) for unrestricted handling of instruments.
Supervises decontamination procedures, ensuring the availability of decontamination supplies (e.g., 10 litres of prepared soap solution, decontamination sprays).
Records estimated radiation exposure to responders (e.g., Responder 1: 0.3 mSv).
Record cumulative radiation dose to the entire team.
Key considerations before action
Patient and environment assessment
Radiation status
Check patient records: Review the patient's medical records for details of radionuclide therapy. For example, I-131, 7.4 GBq, administered 03/01/2025 09:00.
Assess radiation level: Take one meter and surface dose rate from the patient to assess the radiation level and prepare accordingly.
Issue pocket dosimeters to the involved staff and record their total reading per episode.
Contamination risks
Assess for potential surface contamination or spills.
Urine contaminations: Most of the radioisotopes used in therapeutic nuclear medicine are excreted through urine, and it can be a significant source of contamination in case of code blue, as the concentration of radioactivity is high, particularly in the first 24-48 hours (~10 MBq/mL I-131).[26]
Vomitus: Vomiting is less frequent but occurs in some patients, leading to radioactive contamination risks. The concentration in vomit is lower than in urine but still significant for contamination control; however, in the early hours of radioiodine therapy, it can be significantly high as iodine therapy is administered orally, and the route of absorption is through the gastric mucosa.
Open wounds or IV site leakage can also be a source of contamination.
Equipment check
Personal protective equipment (PPE):
20 sets of disposable gowns, gloves, masks, and shoe covers.
Ensure the availability of pocket dosimeters for radiation monitoring.
Monitoring devices:
Properly calibrated survey meter (for dose rate measurements).
Contamination monitor (for detecting surface contamination).
Decontamination supplies:
10 absorbent pads (for spills).
3 lead-lined waste bins (for segregating radioactive waste).
Absorbent sheets (to cover surfaces and prevent contamination spread).
5L liquid soap for cleaning and decontamination of the ward.
Bind-It or Radiac Wash solutions for radioactive contamination removal.
Radioactive symbol stickers (for marking contaminated areas and waste).
Communication protocol
Internal communication
Announce for Code Blue on the hospital's Public Address (PA) system and or
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Dial Code Blue Help line number, e.g., 2222, and state, e.g.:
"Code Blue, High-Dose Therapy Ward, Room 19, radioactive patient."
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Notify the RSO & Nuclear Medicine Physician:
Primary contact (e.g., xxxxx: 00000- 00000).
Secondary contact (e.g., yyyyy: 00000-00000).
External team coordination
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Pre-action briefing: The Hospital Code Blue Team is to be briefed about:
"Patient given radioiodine solution (I-131), 7.4 GBq, 24 hr post-dose; PPE required & Thyroid protection required."
Ensure stable iodine is administered as per the doses mentioned in the next section
Stable iodine administration (radioiodine patients)
In a high-dose therapy ward, the patients treated with radioactive iodine (e.g., I-131), apart from radiation exposure, pose an additional risk of internal contamination to the rescuer, as it can enter the body via inhalation, ingestion, and dermal absorption.[27] To mitigate these risks, the use of appropriate personal protective equipment (PPE), including gloves, masks, and protective clothing, is essential to prevent internal uptake and secondary thyroid injury.[27,28]
Stable (non-radioactive) iodine prophylaxis, such as potassium iodide (KI), is considered a situational and context-dependent protective option for responders involved in Code Blue events involving I-131–treated patients. International guidance recommends that iodine thyroid blocking be implemented only when there is a credible risk of radioactive iodine intake, rather than as a routine or mandatory intervention for all responders.[15,29] Accordingly, KI administration should be considered only after a risk– benefit assessment that accounts for anticipated exposure duration, proximity to the patient, likelihood of inhalation or ingestion, and institutional policy.[15,29] Decisions regarding KI use should be taken within the framework of the institution's emergency preparedness arrangements, typically under the guidance of the RSO in consultation with the Nuclear Medicine Physician, consistent with regulatory expectations for justified and optimised protective actions.[14]
Stable iodine effectively blocks thyroidal uptake of radioactive iodine by saturating the thyroid gland with non-radioactive iodine. When administered within 1 hour of exposure, KI can reduce thyroid uptake of I-131 by up to 80%, and remains partially effective (40-50%) if given within 2-3 hours post-exposure.[15,30] Accordingly, early administration of KI is important in selected emergency scenarios involving iodine radionuclides where thyroid blocking is justified. [Table 1] provides the recommended dosages for administering stable iodine to individuals of different ages and genders in terms of different forms of stable iodine available in the market, along with the number of doses, whereas [Table 2] shows its efficacy when administered at different time intervals.[15,31,32]
| Age group | If the anticipated thyroid dose (in cGy) | Iodine (mg) | KI (mg) | KIO3 (mg) | Dose | Lugol’s iodine (5%) | Number or fraction |
|---|---|---|---|---|---|---|---|
| Adults (>18 years but <40 years) | 10 | 100 | 130 | 170 | 2 drops | 20 drops | 2 |
| Adults (>40 years) | 500 | 100 | 130 | 170 | 2 drops | 20 drops | 2 |
| Pregnant women (regardless of age) | ≥5 cGy | 100 | 130 | 170 | 2 drops | 20 drops | 2 |
| Breastfeeding women | ≥5 cGy | 100 | 130 | 170 | 2 drops | 20 drops | 2 |
| Children (3-≤18 years)* | ≥5 cGy | 50 | 65 | 85 | 1 drop | 10 drops | 1 |
| Infants (1 mo-3 yrs) | ≥5 cGy | 25 | 32 | 42 | 1/2 | 5 drops | 1/2 |
| Neonates (<1 mo) | ≥5 cGy | 12.5 | 16 | 21 | 1/4 | 2 – 3 drops | 1/4 |
| Timing | Thyroid dose reduction (%) | Action window |
|---|---|---|
| Before exposure | 100% | ≤24 hr pre-event |
| 1 Hour post-exposure | 80% | ≤2 hr post-event |
| 6 Hours post-exposure | 50% | ≤8 hr post-event |
| 1 Day post-exposure | Negligible | Avoid |
Eligibility, contraindications, and institutional discretion
KI prophylaxis should not be administered indiscriminately. Authoritative guidance identifies known contraindications, including iodine hypersensitivity, active thyroid disease (e.g., Graves' disease or thyroiditis), dermatitis herpetiformis, and certain autoimmune conditions.[15,29] Routine KI administration is generally recommended for children, pregnant and lactating women, and younger adults (<40 years). In comparison, its use in older adults requires careful consideration because of reduced benefit and higher risk of adverse effects.[29] Pregnant and lactating staff require special consideration due to potential foetal and neonatal thyroid effects, and KI use in these groups should be carefully justified and documented.[15,29] In addition, institutions may define eligibility criteria and documentation requirements in accordance with national regulations and occupational health policies.[14]
Table 1] summarises the thyroid dose thresholds for different population groups at which intervention is recommended only when internal contamination with radioactive iodine is expected to exceed these levels.
Administration protocol
Who: Ward sister-in-charge dispenses from stock.
How:
Provide 1 potassium iodide (KI) tablet (130 mg) dissolved in water. If using SSKI ( 50 mg per drop), administer 2 drops diluted in water. If using 5% Lugol's iodine (5% solution; 20 drops = 100 mg iodine), administer 20 drops in water. Prepare the dilution using 100-150 ml of water in a disposable paper cup.
Log administration details (e.g., "14:30, Nurse A").
Inventory management
Stock: 50 KI tablets (130 mg each) or 2 bottles (10 mL each) of SSKI liquid, stored in a locked cabinet.
Expiry Check: Monthly audit; replenish near-expiry stock and discard expired medicines.
Implementation note
Label cabinet: "Stable Iodine - Emergency Use Only".
Annual training: Staff must attend iodine administration workshops.
Code blue management protocol
CPR protocol and radiation safety
Primary responders:
CPR: Start within 1 min (e.g., 14:33); 100-120/min, 5 cm depth (adult), 4 cm in infants and children.
Continue: Until Hospital Code Blue Team arrives (target: ≤5 min).
Team arrival:
PPE provision: Supply 5 extra sets (gowns, gloves, TLDs) from ward stock.
Briefing: "Patient on I-131, 7.4 GBq, 48 hr post-dose; risks: thyroid uptake, fluid contamination."
KI: Offer 130 mg KI to team; log administration.
Containment:
Fluids: Collect vomit/urine with absorbent pads; seal in 3-6 mm thick waste bags (label: "Radioactive, I-131, 03/03/2025").
Check: Use contamination monitor.
CPR guidelines (AHA, 2020):
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Adult (puberty and older):
Pulse: Carotid, ≤10 sec; if absent, begin compressions.
Rate: 100-120/min (use metronome app if available).
Depth: 5-6 cm (place backboard if bed is soft).
Airway: Head tilt-chin lift (jaw thrust if neck injury); Ambu bag (500-600 mL tidal volume per breath).
Compression-Ventilation Ratio: 30:2 (single or two rescuers)
Switching compressor: every 2 minutes or ~200 compressions
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Child (1-8 years):
Pulse: Carotid or femoral.
Technique: 1 or 2 hands depending on size (e.g., ~10 kg: 1 hand).
Depth: About 5 cm.
Compression-Ventilation Ratio:
- Single rescuer: 30:2
- Two rescuers: 15:2
-
Infant (<1 year):
Pulse: Brachial.
Technique:
- Single rescuer: 2-finger chest compression.
- Two rescuers: 2-thumb encircling technique.
Depth: About 4 cm (1.5 inches).
Compression-Ventilation Ratio:
- Single rescuer: 30:2
- Two rescuers: 15:2
Documentation:
-
Recorder uses pre-printed form:
"Arrest noted at 16:30."
"Initial rhythm: VF via monitor."
"CPR started at 16:31."
"Epinephrine 1 mg IV push at 16:32."
"200 J biphasic defibrillation at 16:33."
"ROSC achieved at 16:43" or "Resuscitation terminated at 16:50."
"Exposure: 0.3 mSv at 1 m (noted at 16:33).
Advanced life support integration
Defibrillation
Adult:
Initial shock: 120-200 J biphasic (or 360 J monophasic).
Subsequent shocks: Use maximum energy (e.g. up to 200 J biphasic) every 2 minutes if ventricular fibrillation (VF) persists.
-
Paediatric:
Initial dose: 2 J/kg (e.g. 20 kg child → 40 J).
Subsequent dose: Escalate to ≥4 J/kg (max 10 J/kg or adult protocol). AHA recommends 2-4 J/kg initial and up to 10 J/kg for refractory cases.
Pad placement: Anterior-apex (or anterolateral); covering pads with a plastic sheet when needed to maintain sterility or reduce contamination.
Airway
Tools: Adult ET tube size 7.0-8.0; paediatric size 3.5-5.0; laryngoscope (e.g. Mac 3 blade).
Technique: Continue chest compressions; pause <10 seconds for intubation; once an advanced airway is placed, ventilate at one breath every 6 seconds (10/min).
Confirmation: Waveform capnography and/or visible chest rise.
Quality metrics
Compression fraction: Target ≥60%, ideally >80% of time compressing in each 2-minute cycle.
Rate: 100-120 compressions per minute; use an audible metronome if available.
Depth: Adults: 5 cm (not >6 cm), Paediatric: 4 cm
Recoil: Ensure complete chest recoil; avoid leaning between compressions
Post-resuscitation care
Airway
Confirm and monitor airway placement using auscultation and waveform capnography [End-Tidal Carbon Dioxide (ETCO2) monitoring] to ensure correct endotracheal tube (ETT) position and assess ventilation efficacy.
Monitoring & vital signs
-
Vital signs: Continuously monitor and maintain target values:
Systolic BP: > 90 mmHg in adults, age-specific targets in paediatrics (e.g., avoiding values below the 5th percentile).
Heart rate and Peripheral Oxygen Saturation SpO2: Maintain SpO2 between 92-98%; HR per age norms.
Electrocardiogram (ECG): Obtain a 12-lead ECG within 10 minutes post-ROSC to identify ST-segment Elevation Myocardial Infarction EMI or other acute cardiac events.
Hemodynamic stabilization
Adults: Maintain systolic BP > 90 mmHg or mean arterial pressure (MAP) >65 mmHg using fluids or vasopressors as needed.
Paediatrics: Target at least the 5th percentile for systolic BP by age (higher thresholds like >10th percentile may offer better outcomes).
Targeted temperature management (TTM)
For comatose adult survivors of cardiac arrest, initiate TTM to maintain core body temperature between 32-36 °C for at least 24 hours. Prevent subsequent fever.
Patient transport (if necessary)
-
Preparation:
Stretcher: Cover with a 0.1 mm plastic sheet.
Monitor: Portable pulse oximeter, BP cuff.
Destination:
Intensive Care Unit (ICU): Corner bed (e.g., Bed 1, minimal exposure to others).
Ward Option: Convert room to ICU (e.g., add ventilator, monitor within 15 min).
Safety:
Path: Clear corridor (e.g., "Radiation Route - No Entry" signs).
Survey: Check stretcher post-move (e.g., <100 cpm).
Dose limits and constraints
Definition of radiation workers
According to the International Commission on Radiological Protection (ICRP, Publication 103) and Atomic Energy (Radiation Protection) Rules, 2004 under the Atomic Energy Act, 1962 (India,[34,4] A radiation worker (also referred to as an occupationally exposed worker) is:
"Any person who is occupationally exposed to radiation" [Radiation Protection Rules, 2004]; and
A person incurring exposure in the course of their work, excluding natural background and exempt practices [ICRP 103].
These workers are distinguished from the general public by the higher annual effective dose limits permitted (typically 20 mSv/year averaged over 5 years, with no more than 50 mSv (30 mSv in India) in any single year), as compared to the 1 mSv/year limit for the public.
In the context of the nuclear medicine and high-dose therapy settings, radiation workers include, but are not limited to:
Nuclear Medicine Physicians
Medical Physicists
Nuclear Medicine Technologists
Nurses whose primary duty station is in nuclear medicine wards or high-dose therapy units
Housekeeping staff, porters, or other auxiliary staff assigned regularly to work in controlled areas (e.g., radiopharmaceutical handling zones, therapy isolation rooms)
These personnel are subject to occupational dose limits and require individual dosimetry monitoring (e.g., Thermoluminescent Dosimeter (TLD), Optically Stimulated Luminescence (OSL), or electronic dosimeters), appropriate training, and inclusion in the institution's radiation protection program.
In contrast, staff whose primary assignment lies outside of nuclear medicine, such as emergency physicians, anaesthesiologists, or general ward nurses, who enter the department only occasionally (e.g., during a Code Blue response or to assist with a specific patient procedure), are not categorised as radiation workers. For such personnel, the dose constraints applicable are those for carers and comforters, typically set at 5 mSv per episode, as per ICRP Publication 103 and IAEA General Safety Requirements (GSR) Part 3, may be applied.
Dose limits for radiation workers
In alignment with IAEA GSR Part 3 and Part 7, dose limits are given in [Table 3]:
| Category | Dose limit | Remarks |
|---|---|---|
| Occupational (normal) | 20 mSv/year, averaged over 5 years, with no more than 50 mSv in any single year | Applies to all designated radiation workers |
| Emergency exposure (life-saving actions) | Up to 500 mSv, with informed consent | Voluntary exposure (e.g., code blue in therapy ward) |
| Emergency exposure (preventing a large exposure) | Up to 100 mSv | For preventing exposure to multiple individuals, e.g., radioactive spill or fire containment |
Dosimetry monitoring:
TLD/OSL badges (typically read monthly or quarterly)
Real-time survey meters or pocket dosimeters for high-risk or emergency situations
Dose limit/constraints for code clue team
Though the IAEA GSR Part 3 and Part 7 set a dose limit of 500 mSv for emergency workers,[14,35] The authors recommend that, for rotation purposes, the dose constraints recommended for comforters and carers can also be applied to Hospital Code Blue Team members. Using a 5 mSv dose constraint can help balance patient care demands with staff safety. However, this should not be treated as a strict rule for team replacement. Life-saving actions must always take priority.
Understanding Dose Constraints vs Dose Limits
It is important to distinguish between dose constraints and dose limits:
Dose limits are legally enforceable upper bounds applied to occupational exposure in classified radiation workers, designed to protect individuals from excessive exposure over time.
Dose constraints, on the other hand, are guidelines or reference levels applied in special cases such as voluntary exposure or infrequent exposure, such as emergency events in a high-dose therapy facility. They are not strict legal limits but are established to keep radiation exposure as low as reasonably achievable (ALARA), particularly when individuals do not routinely work with radiation.
The distinction between a carer and a comforter has been clearly defined when comparing two clinical settings.[36] A nurse assisting with a radiology procedure while wearing protective gear does so as part of her professional responsibility and is therefore a Carer. A child's mother who stays in the imaging room to reduce the child's anxiety participates voluntarily and is classified as a comforter.
In a similar way, the Code Blue team receives radiation exposure as part of their professional responsibility to resuscitate a patient and applying comforter-and-carer dose constraints becomes reasonable. A dose constraint of 5 mSv per intervention, recommended by the ICRP, can serve as a practical guide for planning team rotation and maintaining psychological reassurance. This value is advisory and may be exceeded, when necessary, as the emergency worker dose limit of up to 500 mSv may apply in life-saving situations. Such exposures are expected to be rare and justified by the clinical context.
Note: The 5 mSv constraint should not be interpreted as a rigid upper limit. In critical, life-threatening events, exceeding this value may be acceptable, provided the exposure is documented, justified, and reviewed by the institution's radiation safety committee.[37]
Recommended management actions
Rotation: If the anticipated exposure could approach or exceed 5 mSv, rotate team members during the intervention to reduce individual doses.
Documentation: Always record exposure using personal dosimeters, preferably with real-time readout.
Death of a patient administered radiopharmaceuticals (e.g., i-131, lutetium-177, terbium-161, actinium-225)
The death of a patient who has been administered radiopharmaceuticals during hospitalisation in a high-dose therapy ward constitutes a radiological emergency. While isotopes such as Lutetium-177, Terbium-161, and Actinium-225 typically do not require prolonged hospitalisation and often exhibit radiation levels at 1 meter that fall within permissible public exposure limits, Iodine-131 (I-131) presents a more significant challenge due to its longer half-life and the higher radiation levels typically involved. Patients treated with high-dose I-131 often require isolation for extended durations, depending on the administered activity.
In the event of an unfortunate death during the isolation period, a structured response is mandated to ensure radiation protection, regulatory compliance, and the respectful handling of the deceased. The IAEA Safety Series No. 63 provides foundational guidance on the management and release of patients' post-radionuclide therapy, including conditions under which autopsy and burial may be permitted.[38] These protocols include containment of the body, regulatory notification, safe storage, handover to relatives, and staff training, all in compliance with AE [34,4], IAEA GSR Pa,[39] and local regulatory frameworks.
If radiation levels exceed public exposure limits, the body must be retained in the hospital mortuary until dose rates fall to acceptable thresholds. This holding period may extend for a considerable period of time, depending on the radionuclide and administered activity. In such situations, institutes may consider obtaining a written informed consent from the patient and their relatives prior to therapy, clearly stating that in case of death, the body will not be released until radiation levels fall below permissible regulatory limits.
However, if the family insists on early release, particularly to meet time-sensitive religious or cultural funeral rites, exceptions may be considered under strict institutional and regulatory oversight. In such cases, and if authorised by national regulations, an autopsy may be performed to surgically remove high-uptake organs, notably the thyroid/remnant thyroid, urinary bladder, and intestines, where radioactivity is concentrated. These organs must be stored for decay in a shielded facility and subsequently disposed of in accordance with national radioactive waste disposal protocols. This procedure must be formally approved by the appropriate regulatory authority (e.g., AERB) and evaluated on a case-by-case basis.
Importantly, IAEA Safety Series No. 63 recommends delaying autopsies in such cases and stipulates that the total radioactive content in the body at autopsy should not exceed 10-600 MBq, depending on local regulatory constraints and facility capabilities.[38] This is to ensure the protection of autopsy personnel and to minimise contamination risk. Supporting case reports and procedural guidance are discussed in the literature.[40]
Containment of the deceased body
Wrapping protocol:
First layer: 0.1 mm thick plastic sheet (e.g., Low-Density Polyethylene LDPE) to contain bodily fluids.
Second layer: Absorbent cotton or cloth to reinforce containment.
Third layer: An additional plastic sheet for double protection.
Stock recommendation: At least 10 body containment kits must be available in the nuclear medicine isolation area.
Radioactive labelling: Attach a waterproof, visible label stating:

Regulatory notification
As this qualifies as a radiological emergency, the regulatory authority must be notified immediately. An incident reporting format is given at [Table 4]. In India, the Atomic Energy Regulatory Board (AERB) and Department of Atomic Energy (DAE) must be informed. The notification via phone should be within 1 hour, followed by an email notification within 24 hours, stating the details such as patient ID, radionuclide administered, dosage, date and time of death, and the radiation survey report. The following contact details are provided as an example based on the Indian Regulatory framework:
| Patient information | ||
|---|---|---|
| Patient ID | ||
| Name, gender, age | ||
| Ward/bed number | ||
| Incident details | ||
| Date/time of incident (e.g., 03/03/2025, 16:30) | ||
| Location (e.g., isolation room 3) | ||
| Description of incident | ||
| Radiation status | ||
| Radioisotope administered (e.g., I-131) | ||
| Dose (e.g., 7.4 GBq) | ||
| Date and time of administration (e.g., 03/01/2025 at 14:30 pm) | ||
| Interventions | ||
| Actions tken | ||
| (e.g., CPR initiated at 14:33) (e.g., Defibrillation 200 J at 14:35) | ||
| (e.g., ROSC achieved at 14:45)| | ||
| Medications administered | ||
| Outcome | ||
| (e.g., patient stabilised, transferred to ICU) | ||
| Radiation exposure assessment | ||
| Personnel exposure (e.g., Nurse A: 0.3 mSv) | ||
| Contamination check (e.g., Urine sealed, <100 cpm)| (e.g., Room surfaces: <50 cpm) | ||
| Radiation safety measures (e.g., Lead shielding used) (e.g., Room decontaminated) | ||
| Signatures | ||
| Code leader | Date: | |
| Radiological safety officer | Date: | |
| Attending physician | Date: | |
Note: Submit this form to the radiation safety office and medical records within 24 hours of the incident.
Head, Radiological Safety Division, AERB Phone No.: +91-22-25990655 Fax: +91-22-25990650
Office: 022-25990656
Department of Atomic Energy Emergency Control Room
Phone No.: +91-22-22023978/22862595
Fax:+91-22-22830441/22862555
Mobile: +919969201364
Inventory and equipment maintenance:
10 radioactive warning labels
10 containment kits
5 lead aprons or vests
1 calibrated survey meter
1 lead-lined storage tray or screen
Post-emergency procedures
Personal decontamination
-
Monitoring:
Dosimeter: Check TLD/pocket dosimeter (e.g., 0.5 mSv total).
Survey: Hands, face, shoes (<100 cpm goal).
-
Procedure:
Remove PPE: Into waste bag (e.g., 50 L capacity, double-lined).
Wash: Soap + lukewarm water (10 L bucket, 5 min scrub); 95% removal expected.
Persistent: Repeat x2; if >100 cpm, use 0.5% hypochlorite (not for I-131, eyes, wounds; rinse with 1 L saline).
Hair: Shampoo rinse (e.g., 500 mL water).
Airborne: Nasal swab (blow into tissue); if >100 cpm, refer to physician.
Medical:
Injuries: Report cuts/burns immediately (e.g., "14:50, Nurse C, hand laceration").
KI: If not given earlier, administer 130 mg for I-131 exposure.
Ward decontamination
-
Waste:
Collect: Pads, gloves, sheets into 50 L bins (label: "Radioactive, 03/03/2025").
RSO: Supervises transfer to decay storage (e.g., 90 days for I-131).
-
Survey:
Tools: Survey meter (e.g., 0-50 mSv/hour), contamination monitor (e.g., 0-10000 cpm).
Goal: <0.05 mSv/hour, <100 cpm on surfaces.
Cleaning:
Step 1: Soap + water (10 L, 1% solution); wipe with 20 swabs (discard each use).
Step 2: If >100 cpm, use 1% acetic acid (5 L); avoid metal corrosion.
Step 3: Dry surfaces; final swab (<50 cpm).
Glassware: Chromic acid (1% solution, 1 L).
Electronics: Isopropyl alcohol (70%, 500 mL).
Stainless Steel: Inhibited phosphoric acid (0.1%, 2 L), then 0.1% nitric acid if needed.
Restocking and maintenance
-
Replace:
PPE: 20 gowns, 40 gloves, 10 masks.
KI: 50 tablets (130 mg).
Supplies: 10 pads, 5 waste bags, 5 plastic sheets.
-
Equipment:
Decontaminate: Defibrillator (alcohol wipe, <50 cpm).
Test: Charge to 200 J, verify Ambu bag seal.
Implementation note: Assign restocking to ward manager (e.g., checklist completed by 16:00); calibrate monitors annually.
Training and drills
Frequency: Semi-annual (e.g., Jan 15, Jul 15).
-
Content:
CPR: AHA scenarios (e.g., VF, 10 min).
Radiation: PPE donning (1 min), KI use, decontamination (20 min).
Participants: All ward staff, Code Blue team, RSOs.
Evaluation: Score response time (e.g., CPR <1 min), contamination control (<100 cpm).
Implementation note: Use a dummy with a 0.1 mSv/hour source; record via video for review.
Safety principles
Time: Limit exposure (e.g., <15 min near patient).
Distance: Maintain 2 m when not intervening (e.g., 0.05 mSv/hour vs. 0.2 mSv/hour at 1 m).
Shielding: Lead aprons (0.5 mm Pb, 50% reduction), portable screens (1 mm Pb).
ALARA: Optimise (e.g., rotate staff, use tongs for waste).
Implementation note: Stock 5 aprons, 2 screens; enforce via signage (e.g., "ALARA Zone").
Educational impact and practice implications
The implementation of a structured Standard Operating Procedure (SOP) for Code Blue management in high-dose radionuclide therapy wards is intended to strengthen emergency preparedness and improve coordination among responding personnel. Unlike conventional Code Blue guidelines or standalone radiation safety documents, this SOP addresses the intersection of acute resuscitation and radiation risk within a single operational framework. By providing clear guidance on radiation safety measures and role-specific responsibilities, the SOP supports a more consistent and organised approach to emergency response in environments where conventional Code Blue protocols may be insufficient.
The SOP outlines structured processes for communication, patient handling, and responder protection. When applied during emergency situations, it is expected to facilitate the timely activation of resuscitation efforts while ensuring that responders maintain appropriate radiation safety boundaries. The integration of resuscitation workflows with radiation-specific controls, including controlled access to isolation rooms and responder dose awareness, represents a key educational contribution beyond standard CPR training. The defined use of personal protective equipment, controlled access to isolation rooms, and adherence to radiation safety perimeters are designed to reduce unnecessary radiation exposure without compromising life-saving interventions.
Regular orientation and familiarisation with the SOP are expected to improve staff confidence and procedural clarity during high-stress situations. Standardised workflows also support smoother coordination between ward staff, nuclear medicine personnel, RSO, and the Hospital Code Blue Team. Overall, the SOP serves as an educational tool aimed at enhancing the quality and safety of emergency response in high-dose radionuclide therapy settings, while ensuring continuity of patient care and protection of healthcare workers.
Clinical implementation and safety considerations
While cardiopulmonary resuscitation (CPR) is universally guided by American Heart Association (AHA) protocols, its application in radioactive environments requires contextual adaptation. Conventional Code Blue algorithms focus primarily on rapid initiation of CPR, defibrillation, and advanced life support, and do not address radiation exposure, contamination risks, or isolation-based workflows. In high-dose radionuclide therapy wards, responders are exposed to additional hazards, including elevated dose rates near the patient and potential contamination from radioactive body fluids such as urine or vomitus.
The SOP integrates the three fundamental principles of radiation protection, i.e. time, distance, and shielding, as discussed in section 3.11, directly into the emergency workflow, alongside prophylactic measures such as thyroid blockade for radioiodine exposure. This operational integration of radiation protection principles within active resuscitation distinguishes the SOP from existing guidance that addresses these domains separately. This integration is intended to ensure that immediate life-saving actions are not delayed, while maintaining occupational dose limits recommended by the International Commission on Radiological Protection (ICRP).[41]
A defining feature of the SOP is the clearly delineated role of the RSO during Code Blue activation. The RSO provides real-time oversight of radiation exposure, supervises contamination control, and ensures appropriate documentation of personnel doses. This interdisciplinary approach aligns with International Atomic Energy Agency (IAEA) recommendations for emergency preparedness in radiological facilities.[14]
STRENGTHS, LIMITATIONS, APPLICABILITY, AND LEARNING NEEDS
The primary strength of the SOP lies in its operational clarity. Responsibilities are explicitly defined for first responders, nurses, physicians, technicians, and the Hospital Code Blue Team, reducing ambiguity during the critical early minutes of resuscitation. Unlike existing literature that treats resuscitation and radiation protection as separate processes, this SOP provides an integrated role-based framework for managing both simultaneously. Evidence from hospital emergency management literature indicates that clearly defined roles and simulation-based training improve response efficiency and clinical outcomes.[1]
The SOP emphasises the importance of isotope-specific training, including thyroid blockade protocols for I-131 exposure and contamination control measures for beta-gamma-emitting radionuclides such as Lu-177 and 131I-mIBG. Regular mock Code Blue drills incorporating radiation safety elements are recommended to enhance preparedness, reduce responder anxiety, and reinforce compliance with both AHA and IAEA guidance.
Ethical considerations are also addressed. The SOP adopts a balanced approach by recommending a dose constraint of <5 mSv per incident for responders, consistent with international guidance, while explicitly recognising that life-saving interventions must always take precedence.[15] Provisions for excluding pregnant staff from direct participation, unless unavoidable, further reflect adherence to occupational radiation protection principles.
This SOP is based on established international guidelines and theoretical dose estimations rather than prospective outcome data. Accordingly, it is intended as a practice-oriented educational framework rather than an outcome-evaluated intervention. Its applicability may vary depending on institutional infrastructure, ward design, shielding arrangements, and staff availability. Local adaptation and institutional risk assessment are therefore essential prior to implementation.
At present, there is limited published literature addressing the integration of Code Blue management with radiation safety in nuclear medicine therapy wards. Most existing guidance focuses on contamination control or radioactive waste management, without addressing acute resuscitation scenarios. In this context, the present SOP serves as an educational framework that may support institutional policy development and staff training in high-dose radionuclide therapy settings.
Ongoing learning needs include structured simulation-based training programs and periodic drills that integrate both resuscitation and radiation safety principles. This SOP is presented as a practice-oriented educational framework developed at a single centre, without formal outcome evaluation; all benefits described are therefore anticipatory, with structured audits, simulation-based assessment, and multicentre collaboration identified as future directions. Future educational initiatives may also include prospective audits focusing on response times, radiation exposure to responders, and contamination control practices. Shared experience across institutions and multicentric learning may further refine best practices and strengthen emergency preparedness in high-dose radionuclide therapy environments.
CONCLUSION
This SOP provides a comprehensive and practical framework for managing Code Blue emergencies in high-dose radionuclide therapy wards, addressing the unique challenges posed by radiation hazards alongside the need for rapid and effective resuscitation. By integrating AHA ALS protocols with radiation safety measures from the International Atomic Energy Agency (IAEA), International Commission on Radiological Protection (ICRP), and other authoritative guidelines, this SOP ensures that healthcare providers can deliver life-saving interventions while minimising external radiation exposure and internal contamination risks. Key features include clearly defined staff roles, step-by-step emergency response protocols, radiation dose constraints (e.g., <5 mSv per episode for non-radiation workers), and robust post-emergency decontamination and postmortem handling procedures. The SOP also emphasises the importance of regular staff training, equipment maintenance, and regulatory compliance to ensure preparedness and safety.
This guideline is designed to be adaptable to nuclear medicine facilities worldwide, offering a replicable model that balances patient care with occupational and environmental safety. Institutions can tailor the protocol to their specific resources, patient populations, and regulatory frameworks, ensuring flexibility while maintaining adherence to international standards. By adopting this SOP, nuclear medicine departments can enhance their emergency preparedness, protect healthcare workers, and support safe and effective patient care in high-dose therapy settings.
Data Availability:
The datasets generated during and/or analysed during the current study are available from the corresponding authors on reasonable request.
Authors' Contributions:
AA, BDT, SP, MKC, VV, SM, RN, JI, and KK contributed to material preparation, data collection, and analysis. DP conceived the study, designed the protocol, and prepared the first draft of the manuscript. All authors contributed to the study conception and design, provided critical feedback on earlier versions of the manuscript, and approved the final version.
Ethical approval:
Institutional Review Board approval is not required.
Declaration of patient consent:
Patient's consent not required as there are no patients in this study.
Conflicts of interest:
There are no conflicts of interest.
Use of artificial intelligence (AI)-assisted technology for manuscript preparation:
The authors confirm that they have used artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript or image creations.
Financial support and sponsorship: Nil
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